Merged citations. Ronald A. DePinho, MD Distinguished University Professor and Past President MD Anderson Cancer Center Dr. Ronald A. DePinho, distinguished university professor and past president at MD Anderson Cancer Center, is an internationally known and respected leader recognized for discoveries in cancer, aging, and neurodegeneration. Exciting new data were also presented regarding the importance of telomerase and telomeres for aging. This "Cited by" count includes citations to the following articles in Scholar. We recently demonstrated that SF2312, a natural product phosphonate antibiotic, is a potent inhibitor of the glycolytic enzyme Enolase with potential utility for the collateral lethality-based treatment of Enolase-deficient glioblastoma (GBM). Merged citations. ... Ronald A. DePinho MD Anderson Verified email at mdanderson.org. Over the years, DePinho, president of the University of Texas M.D. Anderson Cancer Center in Houston, TX, and a recently elected member of the National Academy of Sciences, has come to be recognized as an influential proponent of translational cancer research, aimed at ushering … with at least one of the words. A hallmark of pancreatic ductal adenocarcinoma (PDAC) is an exuberant stroma comprised of diverse cell types that enable or suppress tumor progression. View Google Scholar Research Papers on Academia.edu for free. This abstract is also presented as Poster A21. Inhibiting glycolysis remains an aspirational approach for the treatment of cancer. where my words occur The ones marked * may be different from the article in the profile. Add co-authors Co-authors. where my words occur The ones marked * may be different from the article in the profile. Provides a search of scholarly literature across many disciplines and sources, including theses, books, abstracts and articles. Ronald A. DePinho 3 & ... Google Scholar; 4. 1999). with at least one of the words. Ronald DePinho has spent most of his waking hours trying to unlock the genetic secrets of aging and cancer. [abstract]. are supported by R01 and U01 grants from the NIH National Cancer Institute and the Robert A. and Renee E. Belfer Foundation. Norman E. Sharpless Director, The National Cancer Institute Verified email at nih.gov. Ronald A. DePinho 3 & ... Google Scholar; 4. Google Scholar. Title. Convinced that most cancers arise through a host of genetic and biological changes, rather than by single mutations as was widely believed, he vowed to tackle cancer in its complexity or not at all. Accelerating structural and functional decline across diverse organ systems is observed in the aged 1, 3, 4.The loss of genome integrity and associated DNA damage signaling and cellular checkpoint responses are well-established intrinsic instigators that drive tissue degeneration during aging 5.Of particular relevance to this study, age-progressive loss of telomere function in mice has …

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